Differences between proteoglycan and glycoprotein

Glycoprotein Proteoglycan
Glycoprotein is s protein with oligosaccharide chains (glycans) covalently attached to their polypeptide side chain.

 

Proteoglycans are a subclass of glycoproteins. Proteoglycan consists of a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s).

 

Glycoprotein’s carbohydrates chain is relatively short. The chains are often branched instead of linear, and may or may not negatively charged. The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate and uronic acid groups.
There are two broad categories of glycoprotein – N-linked or O-linked saccharides. Proteoglycans can be categorized depending upon the nature of their glycosaminoglycan chains.
Glycoproteins are found on cell surfaces. Most of them are integral membrane proteins, with carbohydrates attached to the peptide chains that are outside of the cell. Proteoglycans are found mainly in connective tissues. They contribute to the organization and physical properties of the extracellular matrix.
Glycoproteins function in cell-cell recognition. Examples: ABO blood group antigens. Proteoglycan function in modulation of cell growth processes or cushioning in joints.

Examples: mucoproteins in extracellular matrix, chondroitin sulphate in cartilages and some other materials in connective tissues.

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2 thoughts on “Differences between proteoglycan and glycoprotein

  1. Misty Lang 06/03/2014 at 3:41 am Reply

    Very helpful, thanks!

  2. Kevin 11/04/2014 at 1:37 pm Reply

    very helpful, simple and easier to understand. thanks

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